Methadone references

  1. College of Physicians and Surgeons of British Columbia methadone for Analgesia Guidelines https://www.cpsbc.ca/files/pdf/DP-methadone-for-Analgesia-Guidelines.pdf
  2. Mary Lynn McPherson, Kathryn A. Walker, P. Davis, Eduardo Bruera, Akhila Reddy, Judith Paice, Kasey Malotte, Dawn Kashelle Lockman, Charles Wellman, Shelley Salpeter, Nina M. Bemben, James B. Ray, Bernard J. Lapointe, Roger Chou. Safe and Appropriate Use of Methadone in Hospice and Palliative Care: Expert Consensus White Paper
  3. Nicholson AB, Watson GR, Derry S, Wiffen, PJ. Methadone for cancer pain. Cochrane Database of Systematic Reviews Feb 2017, version 4
  4. www.palliativedrugs.com Principles of use of analgesics- added June 2008. Accessed June 2017.
  5. Twycross Robert, Wilcox Andrew, Howard. Paul Palliative Care Formulary Eighth Edition (PCF8) p 478-479, Methadone Monograph and Quick Clinical Guide: use of methadone for cancer pain.
  6. Dickman, A, Schneider, J. The Syringe Driver, Oxford University Press, Third edition. Oxford 2016.
  7. British National Formulary. BMJ Publishing Group and RPS Publishing Group, London. Number 76, Sept 2018.
  8. Aronson, JK. Meyler’s Side effects of drugs-fifteenth edition. Updated September 2008.
  9. Stockley Editorial Team. Stockley’s Interaction Alerts. Updated September 2008.
  10. Leavitt, S. Methadone Drug Interactions. Available at www.atforum.com/pdf/Drug_interactions.pdf
  11. M Stewart B. Leavitt, MA, PhD; Executive Director. Methadone-Drug* Interactions (*Medications, illicit drugs, & other substances) , Pain Treatment Topics; January 2006 http://accurateclinic.com/wp-content/uploads/2016/03/Methadone-Drug-Interactions.pdf
  12. Morley JS, Makin MK. The use of methadone in cancer pain poorly responsive to other opioids. Pain Reviews, 1998; 5: 51-58.
  13. Ashley, C, Dunleavy, A. The Renal Drug Handbook-4th Edition. CRC Press, 2014
  14. NICE Clinical Guideline CG140- Opioids in Palliative Care. Published May 2012, updated August 2016.
  15. https://www.gov.uk/drug-driving-law Accessed April 2019. Methadone maximum legal blood concentration to drive: 500µg/L
  16. Shahab J, Willis D. Methadone as an adjuvant analgesic. BMJ Supportive & Palliative Care Published Online First: 01 March 2024. doi: 10.1136/spcare-2023-004674
  17. Twycross Robert, Wilcox Andrew, Howard. Paul Palliative Care Formulary Eighth Edition (PCF8) p 474

Disclaimer (SPAGG - Rewrite)

This Guide is intended for use by healthcare professionals and the expectation is that they will use clinical judgement, medical, and nursing knowledge in applying the general principles and recommendations contained within. They are not meant to replace the many available texts on the subject of palliative care.

Some of the management strategies describe the use of drugs outside their licensed indications. They are, however, established and accepted good practice. Please refer to the current BNF for further guidance.

While WMPCPS takes every care to compile accurate information , we cannot guarantee its correctness and completeness and it is subject to change. We do not accept responsibility for any loss, damage or expense resulting from the use of this information.